手性有機(jī)小分子催化劑因具有反應(yīng)條件溫和、環(huán)境友好、催化劑易于回收利用、符合綠色化學(xué)的要求等優(yōu)點(diǎn),成為近年來(lái)不對(duì)稱(chēng)催化領(lǐng)域發(fā)展起來(lái)的一個(gè)研究熱點(diǎn)。其中,手性環(huán)胍類(lèi)有機(jī)小分子催化劑可用于不對(duì)稱(chēng)的Michael加成反應(yīng)、Mannich反應(yīng)、脫羧反應(yīng)、胺化反應(yīng)及炔烴的手性連烯重排反應(yīng)等等,并可實(shí)現(xiàn)良好收率和立體選擇性,充分顯示了手性環(huán)胍小分子催化劑在不對(duì)稱(chēng)反應(yīng)中的巨大潛力。
產(chǎn)品性質(zhì)穩(wěn)定,易于儲(chǔ)存;
反應(yīng)條件溫和,反應(yīng)易于操作;
反應(yīng)底物范圍廣,可催化多種反應(yīng)類(lèi)型;
催化劑無(wú)金屬殘留,可用于制藥或香精香料生產(chǎn);
高度優(yōu)勢(shì)的產(chǎn)品價(jià)格,齊全的包裝規(guī)格,國(guó)內(nèi)現(xiàn)貨量充足。
■ 手性五元二環(huán)胍
產(chǎn)品名稱(chēng)
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CAS
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(2S,6S)-雙芐基五元二環(huán)胍
(2S,6S)-2,6-Di-benzyl-2,3,5,6-tetrahydro-1H-imidazo[1,2-a]imidazole
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877773-30-3
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(2S,6S)-雙叔丁基五元二環(huán)胍
(2S,6S)-2,6-Di-tert-butyl-2,3,5,6-tetrahydro-1H-imidazo[1,2-a]imidazole
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877773-38-1
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■ 產(chǎn)品技術(shù)應(yīng)用
1. Biomimetic Enantioselective Decarboxylative Reactions catalysed by chiral bicyclic guanidine;
2. Bicyclic guanidine-catalyzed enantioselective Phospha-Michael reaction;
3. Bicyclic Guanidine-Catalyzed Direct Asymmetric Allylic Addition of N-Aryl Alkylidene-Succinimides;
4. Enantioselective Protonation Catalyzed by a Chiral Bicyclic Guanidine;
5. Chiral bicyclic guanidine catalysed Mannich reaction;
6. Enantiodivergent and g-Selective Asymmetric Allylic Amination;
7. Enantioselective Synthesis of Chiral Allenoates by Guanidine-Catalyzed Isomerization of 3-Alkynoates.
Ref.:
[1].Chem. Eur. J.2011, 17, 8363 - 8370;
[2].Chemical Commununications,2007, 47, 5058-5060;
[3].Chem. Eur. J.2010, 16, 12534 - 12537;
[4].Angew. Chem. Int. Ed.2008, 47, 5641 - 5645;
[5].a).Chem. Eur. J.2011, 17, 3571 - 3574;b).Chem. Eur. J.2010, 16, 779 -782;
[6].Angew. Chem. Int. Ed.2012, 51, 1 - 6;
[7].J. Am. Chem. Soc.2009, 131, 7212 - 7213.
■ 其它手性有機(jī)小分子催化劑
產(chǎn)品名稱(chēng)
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CAS
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(S)-(+)-2-(苯胺甲基)吡咯烷
(S)-(+)-2-(Anilinomethyl)pyrrolidine
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64030-44-0
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L-氮雜環(huán)丁烷-2-羧酸
L-Azetidine-2-carboxylic acid
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2133-34-8
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(S)-α,α-雙[3,5-雙(三氟甲基)苯基]-2-吡咯烷甲醇三甲基硅基醚
(S)-α,α-Bis[3,5-bis(trifluoromethyl)phenyl]-2-pyrrolidinemethanol trimethylsilyl ether
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848821-61-4
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α,α-二苯基-N-甲基-D-脯氨醇
α,α-Diphenyl-N-methyl-D-prolinol
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144119-12-0
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α,α-二苯基-N-甲基-L-脯氨醇
α,α-Diphenyl-N-methyl-L-prolinol
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110529-22-1
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(R)-(+)-2-(二苯基甲基)吡咯烷
(R)-(+)-2-(Diphenylmethyl)pyrrolidine
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22348-31-8
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(S)-2-二苯基甲基吡咯烷
(S)-2-Diphenylmethylpyrrolidine
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119237-64-8
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(R)-(+)-α,α-二苯基脯氨醇
(R)-(+)-α,α-Diphenyl-2-pyrrolidinemethanol
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22348-32-9
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(S)-(-)-α,α-二苯基-2-脯氨醇
(S)-(-)-α,α-Diphenyl-2-pyrrolidinemethanol
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112068-01-6
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α-甲基-L-脯氨酸
α-Methyl-L-proline
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42856-71-3
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L-脯氨酸
L-Proline
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147-85-3
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(S)-(+)-1-(2-吡咯烷甲基)吡咯烷
(S)-(+)-1-(2-Pyrrolidinylmethyl)pyrrolidine
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51207-66-0
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N-[(2S)-2-吡咯烷甲基]-三氟甲磺酰胺
N-[(2S)-2-Pyrrolidinylmethyl]-trifluoromethanesulfonamide
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782495-18-5
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(S)-(-)-5-(吡咯烷-2-基)-1H-四唑
(S)-(-)-5-(2-Pyrrolidinyl)-1H-tetrazole
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33878-70-5
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L-4-羧基噻唑烷
L-4-Thiazolidinecarboxylic acid
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34592-47-7
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